Thymosin Alpha-1

Thymosin Alpha-1  10 mg

You can now buy Thymosin Alpha-1, a peptide made up of 28 amino acids, 10mg vial, for research purposes at Orion Peptides. Thymosin Alpha-1 (TA1) is a small peptide made from a larger protein called prothymosin alpha. In the human body, this protein is produced by the PTMA gene.

What is Thymosin Alpha-1?

Thymosin Alpha-1, also known as the TA1 peptide, is a version of a naturally occurring peptide found in the thymus gland. It was the first peptide from thymosin fraction 5 to be fully studied and synthesized.

Thymosin Alpha- 1 is naturally found in the thymus gland, and it has been studied for immune-related activity in laboratory models. The naturally occurring TA1 supports T cells, as observed in immune cell interaction studies.

In research settings, it is observed to influence T cells. It may support T cell growth and activation in laboratory studies. It is also studied for its effects on natural killer cells and dendritic cells. These cells are important in syntheticmune system research models.

It has also been observed to affect cytokine signaling. Cytokines are small signals used in immune communication in lab studies.

Amino Acid Sequence and Molecular Properties of Thymosin Alpha-1

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Molecular Formula:  C₁₂₉H₂₁₅N₃₃O₅₅ Molecular Weight:  3,108.3 Da

Why Researchers Study Thymosin Alpha-1?

Thymosin Alpha 1 has gained popularity among peptide researchers because of the following main reasons.

1. Natural Immune-Related Peptide

Thymosin Alpha-1 is a naturally occurring peptide found in the thymus. In laboratory studies, it is used to understand how immune-related peptides behave in biological systems.

2. Role in Immune System Studies

In research settings, it is studied for its effects on immune signaling pathways. Scientists observe how it interacts with immune cells under controlled experimental conditions.

3. Effects on Immune Cells in Research Models

Laboratory studies examine its impact on T cells, dendritic cells, and natural killer cells. These studies focus on how it influences cell activation and communication in vitro and in experimental models.

4. Use in Immunology Research

It is commonly included in immunology research to study immune regulation mechanisms. Researchers use it to better understand how small peptides can affect immune system responses at a cellular level.

Difference Between Thymosin Alpha-1 and Thymosin Beta-4

Feature	Thymosin Alpha-1 (TA1)	Thymosin Beta-4 (TB4)
Origin	Derived from prothymosin alpha	Naturally occurring actin-sequestering peptide
Amino acids	28 amino acids	43 amino acids
Main source in body	Thymus gland	Found widely in many tissues
Protein family	Thymosin fraction 5–related peptide	Beta thymosin family
Primary biological role (lab studies)	Immune signaling research	Cell migration and tissue repair research
Key research focus	Immune cell regulation (T cells, dendritic cells, NK cells)	Wound healing, cell movement, tissue regeneration
Mechanism studied in labs	Modulation of immune response pathways	Regulation of actin in cell structure and movement

Different Variations of Thymosin Alpha-1 at Orion Peptides

At Orion Peptides, you can buy two different variations of Thymosin Alpha-1 for research purposes:

• Thymosin Alpha-1 5mg
• Thymosin Alpha-1 10mg

Important Research Disclaimer:

Thymosin Alpha-1 is an investigational novel drug used only for research purposes. It is not approved by the F.D.A. for human consumption, immune therapy, vaccine enhancement or any other medical use. This product is for researchers use only and not intended for diagnostic or therapeutic purposes. Not for individual or private use.

Reference Studies:

https://pubmed.ncbi.nlm.nih.gov/31555601/ https://pubmed.ncbi.nlm.nih.gov/38903817/ https://pubmed.ncbi.nlm.nih.gov/3882244/ https://pubmed.ncbi.nlm.nih.gov/2126987/