Kisspeptin-10

Do you want to purchase Kisspeptin-10 5mg? Kisspeptin-10 is a synthetic decapeptide analogue derived from the Kiss1 gene product, and it represents one of the most valuable research tools in reproductive neuroendocrinology. This approach is commonly used in laboratory studies to dissect the regulatory pathways of the hypothalamic-pituitary-gonadal (HPG) axis, GnRH pulsatility, puberty initiation, and fertility. Important Research Disclaimer: Kisspeptin-10 is FOR RESEARCH USE ONLY. It is not approved by the F.D.A. for use in humans, nor for fertility treatment, hormone regulation, or any therapeutic purpose. This product is for research use only and not for use in therapeutic procedures, by any qualified researcher conducting in-vitro, ex-vivo or animal studies, under controlled laboratory conditions. Not for human or personal usage.

What Is Kisspeptin-10?

Kisspeptin-10 (peptide YNWNSFGLRF-NH₂) consists of 10 amino acids. Kisspeptin-10 is the shortest biologically active fragment of full-length Kisspeptin-54, and serves as a potent agonist of the kisspeptin receptor (KISS1R / GPR54), a G-protein-coupled receptor primarily expressed in gonadotropin-releasing hormone (GnRH) neurons within the hypothalamus.

Molecular Formula:

C₆₃H₈₃N₁₇O₁₄

Molecular Weight:

1,300.44 Da Kisspeptin-10 has been identified as a key upstream regulator of gonadotropin-releasing hormone (GnRH) release in studies. It acts as a stimulus to GnRH neurons that, in turn, stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland.  Specifically, the 5mg vial size is designed for acute experiments, dose-finding studies, and pilot protocols where smaller amounts are desired.

How Kisspeptin-10 Differs from Kisspeptin-54

Kisspeptin-10 is an endogenous C-terminal decapeptide fragment of Kisspeptin-54. While both bind to and activate the KISS1R receptor with high potency, Kisspeptin-10 is significantly smaller, more stable in solution, and easier to handle in laboratory workflows.  The naturally occurring full-length form, Kisspeptin-54 (K54), is quite susceptible to rapid degradation and costly for frequent usage in an experimental setting.  So Kisspeptin-10 is widely used in a lot of preclinics as it achieves similar receptor activation and downstream hormonal effects (GnRH, LH, FSH release) with superior practicality than its predecessors, which makes it the preferred choice for many after 1st few years of use for in-vitro, cell culture & acute in-vivo protocols.

Research-Based Benefits of Kisspeptin-10

In the laboratory and preclinical research, Kisspeptin-10 has been studied in relation to a few salient features:

1. Programmed Release of GnRH (Strongly Stimulating)

Kisspeptin-10 has been shown to potently stimulate KISS1R in GnRH neurons, resulting in sustained amplitude pulsatile secretion of GnRH from hypothalamic explants and animal models. This is known to be one of the most potent stimulants for GnRH release.

2. Regulation of LH and FSH secretion

Kisspeptin-10 treatment findings 12 clearly demonstrate increased plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in a dose-dependent manner, with similar responses seen between male and female animal paradigms.

3. Puberty onset and reproductive development

Preclinical data from rodent and primate systems have shown that Kisspeptin-10 advances the onset of pubertal markers, restores reproductive function in hypogonadal states, and plays an essential role in determining the age of onset for puberty events in a research environment.

4. Neuroendocrine Control of Fertility

Kisspeptin-10 is commonly employed to investigate the central mechanisms of fertility, seasonal breeding, and hormonal feedback loops. It also helps researchers understand how metabolic and stress signals affect reproductive function.

5. Promise in Reproductive Endocrinology Studies

Kisspeptin-10 has become an important agent to study infertility models, hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS) analogs & hypothalamic amenorrhea in experiments. Noted that all the benefits mentioned are based on preclinical and animal studies, and a few human studies at an early stage. These are not therapeutic claims. The research peptide form is not safe or effective in humans and needs more research to prove these claims.

Product Specifications – Kisspeptin-10 5mg

Peptide: Kisspeptin-10 Formulation/presentation: 5 mg lyophilized powder in a vial Purity: Research grade (≥98% by HPLC) Content: Lyophilized for maximum stability. Forms: The kit is intended for laboratory research only Kisspeptin-10 5mg is a unique, potent, and selective research tool for scientists investigating the hypothalamic-pituitary-gonadal axis, reproductive neuroendocrinology, pulsatile GnRH action, puberty processes, and fertility control.

References

1. Gottsch ML, et al. Neuroendocrine reproductive axis signaling by Kisspeptin-GPR54 Mol Cell Endocrinol. 2006;254-255:91-96.
2. Seminara SB, et al. The GPR54 gene as a control of puberty. N Engl J Med. 2003;349(17):1614-1627.
3. Smith JT, et al. Kisspeptin is a critical regulator of gonadotropin secretion. Endocrinology. 2006;147(3):1154-1159.
4. Dhillo WS, et al. Gonadotropin-releasing activity of kisspeptin-10 in females. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
5. Messager S, et al. Kisspeptin directly induces gonadotropin-releasing hormone release through G protein-coupled receptor 54. Proc Natl Acad Sci USA. 2005;102(5):1761-1766.