Selank

Price range: $42.00 through $62.00

Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin.

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Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. It consists of the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, augmented with N-terminal acetylation to increase stability and resistance to enzymatic degradation. Selank is studied in laboratory settings for its action on neurotransmitter modulation and pathways associated with anxiety, cognitive capacity, and immune-neuroendocrine processes. Selank is supplied as a high-purity lyophilized powder (≥99% via HPLC) in ampoules containing 5 mg or 10 mg. It is intended strictly for in vitro and in vivo laboratory research only — not for human consumption, therapeutic use, or any non-research purpose. For research use only. Not for human consumption.

Selank Mechanism of Action in Research

In experimental models, Selank influences multiple neurotransmitter systems. It decreases enkephalinase activity, stabilizing endogenous enkephalins and augmenting opioid tone. It alters serotonin metabolism through inhibition of enkephalin-degrading enzymes and modulation of 5-HT turnover. GABAergic transmission is influenced, resulting in anxiolytic-like effects without concomitant sedative effects in animal behavioral models. Selank enhances BDNF expression in hippocampal and cortical regions, supporting research on neuroplasticity. In stress models, it exhibits immunomodulatory activity by modulating IL-6 (interleukin-6), IL-10, and other cytokines. These combined mechanisms are explored in anxiety, cognition, stress resilience, and neuroinflammation research.

Selank Peptide Sequence

Selank is a linear N-terminally acetylated heptapeptide:

Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro (Ac-TKPRPGP)

Molecular Formula:

C₃₃H₅₇N₁₁O₉

Molecular Weight:

751.87 Da

CAS Number:

129954-34-3 The sequence is derived from tuftsin (Thr-Lys-Pro-Arg) with the addition of Pro-Gly-Pro to enhance stability and biological activity.

Research Studies About Selank and Its Effect

Preclinical studies have investigated Selank in anxiety, stress, and cognitive function models. Selank (100–300 µg/kg i.p.) decreased anxiety-like behavior in rodent behavioral tests such as elevated plus-maze and open-field without affecting motor function or causing sedation. It restored serotonin and enkephalin activity to normal levels in midbrain regions affected by chronic stress or immobilization. Selank increased acquisition and retention in passive avoidance and Morris water maze paradigms, possibly through upregulation of BDNF in learning and memory models. Immunomodulatory effects include modulation of IL-6/IL-10 balance and reduction of pro-inflammatory markers in acute traumatic stress–induced immune suppression. In vitro studies suggest Selank affects cytokine release and promotes neuroprotection in glial cells. Selank remains investigational. No large-scale human trials have been conducted, and it is not approved for any therapeutic purpose. Ongoing research continues to evaluate its potential in anxiety, cognitive, and neuroinflammatory models.

Why You Should Buy Selank 10 mg

Selank 10 mg provides a larger quantity suitable for long-term or repeated experimental protocols. This vial size is ideal for multi-dose studies, extended-duration experiments, or research requiring higher total quantities across multiple runs. It offers increased flexibility when preparing working solutions for in vivo behavioral experiments, neurochemical assessments, or cytokine assays conducted over weeks to months. The 10 mg specification maintains ≥99% purity and lyophilized stability while supporting larger-scale projects that require fewer reorders. When scaling up from pilot studies or maintaining consistent dosing across larger sample groups, researchers often select the 10 mg format.

How To Handle Selank 10 mg

Handling Tips for Selank 10 mg

Do not shake vigorously (gently swirl if needed).
Use sterile technique during reconstitution.
Wipe vial stopper with alcohol before each use.
Minimize time outside the refrigerator.
Discard if solution becomes cloudy or changes color.

Important Disclaimer

Selank is an investigational research peptide intended strictly for in vitro and in vivo laboratory studies. It is not approved for human therapeutic, anxiolytic, cognitive, or medical use by the FDA, EMA, or any other regulatory authority. It falls under non-approved substances (WADA S0 subcategory). Human outcomes do not correlate with preclinical data. Safety, efficacy, or benefits in humans have not been established. Potential risks may include immunogenicity or impurities. Handle only within qualified research institutions under proper institutional oversight. Not for human or veterinary use — sold exclusively for laboratory research purposes.